| Bioactivity | TYK2?JH2-IN-1-d3 is the a deuterated, orally active and selective TYK2 inhibitor (compound 4h), targeting to JH2 domain (IC50=0.1 nM)[1]. |
| Target | TYK2 JH2 domain |
| Name | TYK2 JH2-IN-1-d3 |
| CAS | 2376999-19-6 |
| Formula | C24H21D3FN9O3 |
| Molar Mass | 508.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Xiao Z, et al. Structure-activity relationship study of central pyridine-derived TYK2 JH2 inhibitors: Optimization of the PK profile through C4' and C6 variations. Bioorg Med Chem Lett. 2023 Jul 15;91:129373. |
TYK2 JH2-IN-1-d3
CAS: 2376999-19-6 F: C24H21D3FN9O3 W: 508.52
TYK2?JH2-IN-1-d3 is the a deuterated, orally active and selective TYK2 inhibitor (compound 4h), targeting to JH2 domain
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